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TC-E-5003

Part Number:EI-HMT-001
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TC-E 5003

N,N'-(Sulfonyldi-4,1-phenylene)bis(2-chloroacetamide)

Selectiveprotein arginine methyltransferase 1 (PRMT1) inhibitor, IC50 = 1.5 µM. Displays no activity against CARM1 and Set7/9 methyltransferases. Inhibits growth of MCF7a breast cancer cells and LNCaP prostate cancer cells. Blocks androgen-induced gene expression in LNCaP cells.

Physical Properties: Brown powder

MW=401.3 C16H14Cl2N2O4S

Analysis: >98% (TLC); NMR (Conforms)

Solubilization: May be dissolved in DMSO (50 mg/ml); or ethanol (nil)

Storage: Store desiccated as supplied at -20°C for up to 2 years. Store solutions at 20°C for up to 1 month. 

Amount: 50 mg