1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one

Splitomicin was initially shown to inhibit Sir2p (the yeast Sirt1 homolog) and create a conditional phenocopy of a sir2 deletion mutant in S. cerevisiae. Cells grown in the presence of the drug have silencing defects at telomeres, silent mating-type loci and the ribosomal DNA. Inhibits all class III HDACs (sirtuins) and alleviates gene silencing in Fragile X mental retardation syndrome. Reverses ischemic preconditioning-induced cardioprotection in a mouse model.

Physical Properties: White powder

MW=198.2 C₁₃H₁₀O₂

Analysis: >98% (TLC); NMR (Conforms)

Solubilization: May be dissolved in DMSO (>25 mg/ml) or ethanol (>25 mg/ml)

Storage: Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20°C for up to 1 month.