Panobinostat

Part Number:EI-HDC-008
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Panobinostat


(E)-N-hydroxy-3-(4-((2-(2-methyl-1H-indol-3-yl)ethylamino)methyl)phenyl)acrylamide;

LBH-589

Panobinostat is a potent inhibitor of class I and II HDACs1. Cotreatment with panobinostat and an HSP90 inhibitor caused synergistic apoptosis in human CML-BC and AML cells2. A potent antimyeloma agent that overcomes drug resistance3.


Physical Properties: 
Off-white powder

MW=349.4 C21H23N3O2

Analysis: >98% (HPLC); NMR (Conforms)

Solubilization: May be dissolved in DMSO (100 mg/ml); or ethanol (5 mg/ml, warm)

Storage: Store desiccated as supplied at -20°C for up to 1 year. Store solutions at -20°C for up to one month.


Amount: 5mg