IOX1
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8-Hydroxy-5-quinolinecarboxylic acid; (5-Carboxy-8HQ)
IOX1 inhibits the JMJD family of 2-oxoglutarate-dependent histone demethylases. IC50 = 0.12, 0.07, 0.2, 0.3, 0.6, and 1 mM for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively1. A broad spectrum 2-oxoglutarate oxygenase inhibitor which may be used to study hypoxic signaling1. Cell permeable
Physical Properties: Yellow powder
MW=189.2 C10H7NO3
Analysis: >98% (HPLC); NMR (Conforms)
Solubilization: May be dissolved in DMSO (20 mg/ml)
Storage: Store desiccated as supplied at ambient temperature for up to 1 year. Store solutions at -20°C for up to 3 months.
Amount: 5 mg
