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HPA (Hexyl-4-pentynoic acid)

Part Number:EI-HDC-004
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Hexyl-4-pentynoic acid


2-(2-propynyl)octanoic acid (racemic); HPA

Hexyl-4-pentynoic acid is a valproic acid analog. Histone deacetylase (HDAC) inhibitor, IC50=13 mM1. More potent and robust than valproic acid at inducing histone hyperacetylation (600% at 50 mM), HSP70 induction and protection against glutamate excitotoxicity in cultured neurons. Cell permeable.


Physical Properties: colorless oil

MW=182.3 C11H18O2

Analysis: >97% (TLC); NMR conforms

Solubilization: May be dissolved in DMSO (25 mg/ml); or Ethanol (25 mg/ml)

Storage: Store as supplied at ambient temperature for up to 2 years. Store solutions at-20°C for up to 3 months.


Amount: 10mg