Daminozide



1-(2,2-Dimethylhydrazide)butanedioic acid; N-(dimethylamino)succinamic acid,

Daminozide is a selective inhibitor of the KDM2/7 JmjC subfamily of histone demethylases. IC₅₀=1.5, 0.55 and 2.1 mM for KDM2A, PHF8 and KDM7A respectively. Highly selective over other subfamily members (KDM3, KDM4, KDM5 and KDM6) as well as other 2-oxoglutarate oxygenases (FIH, PHD2 and BBOX1), IC₅₀>100 mM

Physical Properties: White powder; MP=158-162°C

MW=160.2 C₆H₁₂N₂O₃

Analysis: 98% (TLC); NMR (Conforms)

Solubilization: May be dissolved in DMSO (50 mg/ml); or water (20 mg/ml, warm)

Storage: Store desiccated as supplied at ambient temperature for up to 3 years. Store solutions at -20°C for up to 3 months.