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DOT1L Methyltransferase

Part Number:HMT-11-101
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Human DOT1L, and its homologs in other species, are unique among the histone lysine methyltransferases in not containing a SET domain and in targeting a specific residue in the histone H3 globular domain (lysine-79; H3K79).Inappropriate recruitment of DOT1L by MLL-fusion proteins is implicated in the development of leukemias.


ACCESSION #: NM_032482

Uniprot Link

INCLUDES AMINO ACIDS: 1-416

TAG(S): N-terminal GST

MW: 80.0 kDa

EXPRESSION SYSTEM: E. coli

SUPPLIED AS: Solution of purified recombinant protein in 25 mM Tris-HCl, pH 7.5, 100 mM NaCl, 0.05% Tween 20, 3 mM DTT, 20% (v/v) glycerol.

STORAGE: -80°C, aliquot and snap-freeze after first use.

 
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