Zebularine
1H-?b-?D-?ribofuranosyl-?2-?pyrimidinone; NSC 309132
DNA methyltransferase
inhibitor which binds covalently to methyltransferases. Re-activates silenced E-cadherin
expression in EBV-harboring Burkitt’s lymphoma Akata cells. Delays tumor growth
and induces apoptosis in a genetically engineered mouse model of breast cancer.
Potentiates differentiation of mesenchymal stem cells into cardiomyocytes. Inhibits
cytidine deaminase (Ki ~ 2 µM). Active in vivo.
Physical Properties: White powder
MW=228.2 C9H12N2O5
Analysis: =98% (HPLC); NMR (Conforms)
Solubilization: May be dissolved in DMSO
(20 mg/ml); or water (20 mg/ml)
Storage: Store desiccated as supplied at -20°C for up to 2 years. Store solutions
at -20°C for up to 1 month.
Amount: 5mg
