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Zebularine

Part Number:EI-DNA-005
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Zebularine

1H-?b-?D-?ribofuranosyl-?2-?pyrimidinone; NSC 309132

DNA methyltransferase inhibitor which binds covalently to methyltransferases. Re-activates silenced E-cadherin expression in EBV-harboring Burkitt’s lymphoma Akata cells. Delays tumor growth and induces apoptosis in a genetically engineered mouse model of breast cancer. Potentiates differentiation of mesenchymal stem cells into cardiomyocytes. Inhibits cytidine deaminase (Ki ~ 2 µM). Active in vivo.

Physical Properties: White powder

MW= 228.2 C9H12N2O5

Analysis: =98% (HPLC); NMR (Conforms)

Solubilization: May be dissolved in DMSO (20 mg/ml); or water (20 mg/ml)

Storage: Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month.


Amount: 5mg