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Your Price:$413.00
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Part Number:HMT-14-109

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WRAD2 is an essential sub-complex of SET1 family H3K4 methyltransferases (human MLLs 1-4; SET1A/B), necessary for complex assembly and full activity. Recent work has shown the WRAD2 complex to have intrinsic, albeit weak, H3K4 methyltransferase activity, making it the first known non-SET domain/non-Dot1L lysine methyltransferase. Unlike SET-domain inhibition, targeting of WRAD2’s MLL regulatory interactions or its methyltransferase activity would represent routes to MLL inhibition that would be specific to the SET1 family. 

ACCESSION #: NM_017588, NM_005057, NM_001105214, NM_0325742

Uniprot Link 

INCLUDES AMINO ACIDS: WDR5 22-334 (C-term.), RbBP5 1-538 (C-term.), Ash2L 2-534 (C-term.), DPY-30 1-99 (C-term.)

TAG(S): N-terminal His-tag on all subunits

MW: 184.0 kDa


SUPPLIED AS: Solution of purified recombinant proteins in 20 mM Tris-HCl, pH 7.5, 300 mM NaCl, 1 mM TCEP (tris(2-carboxyethyl)phosphine HCl), 10% (w/v) glycerol, 1 µM ZnCl2.

STORAGE: -80°C, aliquot and snap-freeze after first use.

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With the largest functional kinase activity assay panel in the industry, RBC provides kinase, epigenetic, and other profiling services to over 590 companies worldwide. RBC specializes in custom assay conditions, high quality reproducible data, and outstanding service.

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