is an essential sub-complex of SET1 family H3K4 methyltransferases (human MLLs 1-4; SET1A/B), necessary for complex assembly and full activity. Recent work has shown the WRAD2
complex to have intrinsic, albeit weak, H3K4 methyltransferase activity, making it the first known non-SET domain/non-Dot1L lysine methyltransferase. Unlike SET-domain inhibition, targeting of WRAD2
’s MLL regulatory interactions or its methyltransferase activity would represent routes to MLL inhibition that would be specific to the SET1 family.
ACCESSION #: NM_017588, NM_005057, NM_001105214, NM_0325742
INCLUDES AMINO ACIDS: WDR5 22-334 (C-term.), RbBP5 1-538 (C-term.), Ash2L 2-534 (C-term.), DPY-30 1-99 (C-term.)
TAG(S): N-terminal His-tag on all subunits
MW: 184.0 kDa
EXPRESSION SYSTEM: E. coli
SUPPLIED AS: Solution of purified recombinant proteins in 20 mM Tris-HCl, pH 7.5, 300 mM NaCl, 1 mM TCEP (tris(2-carboxyethyl)phosphine HCl), 10% (w/v) glycerol, 1 µM ZnCl2.
STORAGE: -80°C, aliquot and snap-freeze after first use.
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