Vorinostat



Suberoylanilide-hydroxamic acid;SAHA

Vorinostat is a potent and selective histone deacetylase inhibitor. Induces apoptosis in a variety of tumor cell lines. Synergizes with kinase inhibitors to kill CNS tumor cells. Prevents diabetes in a mouse model by immunoregulation and b-cell protection. Cell permeable.

Physical Properties: White powder

MW=264.3 C₁₄H₂₀N₂O₃

Analysis: >98%; NMR (Conforms)

Solubilization: May be dissolved in DMSO (50 mg/ml); or Ethanol (2 mg/ml)

Storage: Store desiccated as supplied at ambient temperature for up to 5 years. Store solutions at -20°C for up to 1 month.

Amount: 10mg