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Your Price:$74.80
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Part Number:EI-MTL-001

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3-Bromo-N-(3-(tert-butylamino)propyl)benzamide, hydrochloride

The DNA damage response protein 53BP1 utilizes its tandem tudor domain to recognize dimethylated lysine 20 on histone (H4K20me2), a modification associated with double-strand DNA breaks. UNC-2170, identified by screening, was found to be a uM ligand for 53BP1 which also demonstrated at least 17-fold selectivity for 53BP1 over other methyllysine binding proteins. The compound functions as a 53BP1 antagonist in cell lysates and suppresses class switch recombination in whole cells, a process requiring a functioning 53BP1 tudor domain.

Physical Properties:  White powder

MW=349.7 C14H21BrN2O• HCl

Analysis:  >98% (TLC); NMR (Conforms)   

Solubilization: May be dissolved in DMSO (40 mg/ml); or water (50 mg/ml)

Storage:  Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 3 months.

Amount: 5 mg

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