Tubastatin A is a potent and selective histone deacetylase 6 (HDAC6)
inhibitor, IC50=15 nM (>1000-fold selective against other HDACs
and 60-fold for HDAC8). Inhibits
TNFa (IC50=272 nM) and IL-6 (IC50=712
nM) in LPS-stimulated human macrophages and displays anti-inflammatory activity
in animal models. Improves survival in animal models of sepsis.
Improves cognition in Alzheimers disease transgenic mice. Cell
Physical Properties: white powder
MW=371.9 C20H21N3O2 ·
Analysis: 99% (HPLC); NMR conforms
Solubilization: May be dissolved in DMSO (50
Store as supplied at -20°C for up to 2 years. Store solutions at -20°C
for up to 3 months.