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Tubastatin A

Your Price:$104.50
In Stock.
Part Number:EI-HDC-013

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Tubastatin A    

N-Hydroxy-4-((2-methyl-3,4-dihydro-1H-pyrido[4,3-b]-indol-5(2H)-yl)methyl)benzamide, hydrochloride


Tubastatin A is a potent and selective histone deacetylase 6 (HDAC6) inhibitor, IC50=15 nM (>1000-fold selective against other HDACs and 60-fold for HDAC8).  Inhibits TNFa (IC50=272 nM) and IL-6 (IC50=712 nM) in LPS-stimulated human macrophages and displays anti-inflammatory activity in animal models. Improves survival in animal models of sepsis. Improves cognition in Alzheimers disease transgenic mice. Cell permeable.


Physical Properties:  white powder

MW=371.9          C20H21N3O2  · HCl

Analysis: 99% (HPLC);  NMR conforms

Solubilization: May be dissolved in DMSO (50 mg/ml)

Storage:  Store as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 3 months.


Amount: 1mg
















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