Trim33a-[PHD-BRD](His)

Part Number:RD-11-243
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A member of the Tripartite Motif (TRIM) family of proteins, TRIM33a functions as an E3 ubiquitin protein ligase for SMAD4. The C-terminally located PHD-bromodomain reader cassette displays a high affinity for histone H3 N-terminal tails with unmodified lysine-4, trimethylated lysine-9 (H3K9me3, bound by PHD) and acetylated lysine-18 (H3K18Ac, bound by bromodomain). The biological roles of TRIM33 include tumor suppression in various tissues, regulation of ALC1 activity in the PARP-dependent DNA damage response, transcriptional regulation in hematopoiesis and regulation of TGF-ß signaling in stem cell differentiation.

ACCESSION #: NM_015906

Uniprot Link

INCLUDES AMINO ACIDS: 885-1091

TAG(S): N-terminal His-tag

MW: 26.5 kDa

EXPRESSION SYSTEM: E. coli

SUPPLIED AS: Solution of purified recombinant protein in 50 mM Tris HCl, pH 7.5, 500 mM NaCl, 1 mM TCEP, 10% glycerol (v/v)

STORAGE: -70°C

 
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