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Tranylcypromine hemisulfate

Your Price:$49.50
In Stock.
Part Number:EI-DEM-007

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Tranylcypromine hemisulfate      

Trans (±)-2-phenylcyclopropanamine; 2-PCPA

Tranylcypromine hemisulfate  is a irreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110) IC50 < 2 mM1,2. Tranylcypromine treatment of P19 embryonal carcinoma cells resulted in global increase of H3K4 methylation along with transcriptional derepression of two BHC110 target genes, Egr1 and Oct4. When combined with CHIR99021, induces the generation of human-induced pluripotent stem cells in the absence of exogenous Sox23.  Reduces proliferation, cell cycle progression and invasiveness of endometriotic stromal cells4. Upregulates CD86 expression in THP1 cells5. Cell permeable and active in vivo.

Physical Properties:  White powder

MW=182.2        C9H11N • 1/2 H2SO4

Analysis:  >98% (TLC); NMR (conforms)

Solubilization: May be dissolved in water (25 mg/ml)

Storage:  Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at  -20°C for up to 1 month.  

Amount: 50mg

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