Sirtinol is a selective sirtuin inhibitor which does not
effect HDAC1, IC50 = 131, 38 and 68 mM for
SIRT1, SIRT2 and Sir2P respectively. Induces apoptotic and
autophagic cell death in MCF-7 human breast cancer cells.
Suppresses survivin expression which correlates with decreased viability in
HT29 colon cancer cells. Displays pro-inflammatory effects in
Physical Properties: Yellow powder
Analysis: >98% (TLC); NMR conforms
Solubilization: May be dissolved in DMSO (35
mg/ml) or ethanol (10 mg /ml)
Store desiccated as supplied at -20°C for up to 2 years. Store solutions
at -20°C for up to 1 month.