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Sirtinol

Part Number:EI-SRT-008
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Sirtinol


2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide

Sirtinol is a selective sirtuin inhibitor which does not effect HDAC1, IC50 = 131, 38 and 68 mM for SIRT1, SIRT2 and Sir2P respectively. Induces apoptotic and autophagic cell death in MCF-7 human breast cancer cells. Suppresses survivin expression which correlates with decreased viability in HT29 colon cancer cells. Displays pro-inflammatory effects in adipocytes.

Physical Properties: Yellow powder

MW=394.5 C26H22N2O2

Analysis: >98% (TLC); NMR conforms

Solubilization: May be dissolved in DMSO (35 mg/ml) or ethanol (10 mg /ml)

Storage: Store desiccated as supplied at -20°C for up to 2 years. Store solutions at-20°C for up to 1 month.


Amount: 5mg