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SirtAct (CAY10591)

Your Price:$93.50
In Stock.
Part Number:EI-SRT-005

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2-?Amino-?N-?cyclopentyl-?1-?(3-?methoxypropyl)-?1H-?pyrrolo[2,?3-?b]quinoxaline-?3-?carboxamide; CAY10591

SirtAct is a Sirt1 activator (233% at 10 mM using the BIOMOL Fluor-de-Lys assay)1    Suppresses TNFa release from THP-1 cells and  stimulates adipogenesis in 3T3L1 cells. SIRT1 stimulation by SirtAct leads to decreased tissue factor mediated thrombogenicity in mice. Inhibits NFkB activation and reduces inflammatory cytokine production in lamina propria mononuclear cells from IBD patients3. Prevents and cures experimental colitis in a mouse model.

Physical Properties:  Olive green powder

MW=367.4        C20H25N5O2

Analysis:  98% (TLC); NMR (Conforms)

Solubilization: May be dissolved in DMSO (50 mg/ml); or ethanol (20 mg/ml, warm)

Storage:  Store desiccated as supplied at -20°C for up to 2 years. Store solutions at  -20°C for up to 3 months.  

Amount: 5mg

With the largest functional kinase activity assay panel in the industry, RBC provides kinase, epigenetic, and other profiling services to over 590 companies worldwide. RBC specializes in custom assay conditions, high quality reproducible data, and outstanding service.

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