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SirtAct (CAY10591)

Part Number:EI-SRT-005
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SirtAct

2-?Amino-?N-?cyclopentyl-?1-?(3-?methoxypropyl)-?1H-?pyrrolo[2,?3-?b]quinoxaline-?3-?carboxamide; CAY10591


SirtAct is a Sirt1 activator (233% at 10 mM using the BIOMOL Fluor-de-Lys assay)1Suppresses TNFa release from THP-1 cells and stimulates adipogenesis in 3T3L1 cells. SIRT1 stimulation by SirtAct leads to decreased tissue factor mediated thrombogenicity in mice. Inhibits NFkB activation and reduces inflammatory cytokine production in lamina propria mononuclear cells from IBD patients3. Prevents and cures experimental colitis in a mouse model.


Physical Properties: Olive green powder

MW=367.4 C20H25N5O2

Analysis: 98% (TLC); NMR (Conforms)

Solubilization: May be dissolved in DMSO (50 mg/ml); or ethanol (20 mg/ml, warm)

Storage: Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 3 months.


Amount: 5mg