Along with its close homolog, SUV39H1, SUV39H2 is responsible for the transcriptionally repressive modification, H3K9me3, in heterochromatin. Mice deleted in both SUV39H2 and SUV39H1 have elongated telomeres, implying a role for these enzymes and H3K9 methylation in regulation of telomere length. Polymorphisms in the human SUV39H2 gene have been associated with complications of type I diabetes and lung cancer risk.
ACCESSION #: NM_001193424
INCLUDES AMINO ACIDS: 46-410 (C-term.)
TAG(S): N-terminal fusion protein with a C-terminal His-tag
MW: 98.8 kDa
EXPRESSION SYSTEM: E. coli
SUPPLIED AS: Solution of purified recombinant protein in 50 mM Tris/HCl, pH 7.5, 500mM NaCl, 20% glycerol, 1mM TCEP
STORAGE: -80°C, aliquot and snap-freeze after first use.
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