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SUV39H1 Methyltransferase

Your Price:$329.00
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Part Number: HMT-11-111

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A SET-domain lysine-methyltransfersase, SUV39H1’s activity is the major source of the transcriptionally repressive modification, H3K9me3, in heterochromatin. The oncoprotein Evi1, which is inappropriately expressed in AML (acute myeloid leukemia) and MDS (myelodysplastic syndrome), recruits SUV39H1, thus enhancing its transcription repressing activity. Depletion of SUV39H1 by shRNA or inhibition with chaetocin induced reexpression of silenced AML tumour suppressor genes, consistent with its potential as a therapeutic target.

ACCESSION #: NM_003173

Uniprot Link

INCLUDES AMINO ACIDS: 44-412 (C-term.)

TAG(S): N-terminal fusion protein with a C-terminal His-tag

MW: 99.5 kDa


SUPPLIED AS: Solution of purified recombinant protein in 50 mM Tris/HCl, pH 8.0, 137 mM NaCl, 5 mM MgCl2, 4 mM DTT, 20% (v/v) glycerol

STORAGE: -80°C, aliquot and snap-freeze after first use.

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We also offer assay services for SUV39H1.

With the largest functional kinase activity assay panel in the industry, RBC provides kinase, epigenetic, and other profiling services to over 590 companies worldwide. RBC specializes in custom assay conditions, high quality reproducible data, and outstanding service.

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