A SET-domain lysine-methyltransfersase, SUV39H1’s activity is the major source of the transcriptionally repressive modification, H3K9me3, in heterochromatin. The oncoprotein Evi1, which is inappropriately expressed in AML (acute myeloid leukemia) and MDS (myelodysplastic syndrome), recruits SUV39H1, thus enhancing its transcription repressing activity. Depletion of SUV39H1 by shRNA or inhibition with chaetocin induced reexpression of silenced AML tumour suppressor genes, consistent with its potential as a therapeutic target.
ACCESSION #: NM_003173
INCLUDES AMINO ACIDS: 44-412 (C-term.)
TAG(S): N-terminal fusion protein with a C-terminal His-tag
MW: 99.5 kDa
EXPRESSION SYSTEM: E. coli
SUPPLIED AS: Solution of purified recombinant protein in 50 mM Tris/HCl, pH 8.0, 137 mM NaCl, 5 mM MgCl2, 4 mM DTT, 20% (v/v) glycerol
STORAGE: -80°C, aliquot and snap-freeze after first use.
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Substantial Discounts Available on Bulk Quantities
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