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SUV39H1 Methyltransferase

Part Number: HMT-11-111
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A SET-domain lysine-methyltransfersase, SUV39H1’s activity is the major source of the transcriptionally repressive modification, H3K9me3, in heterochromatin. The oncoprotein Evi1, which is inappropriately expressed in AML (acute myeloid leukemia) and MDS (myelodysplastic syndrome), recruits SUV39H1, thus enhancing its transcription repressing activity. Depletion of SUV39H1 by shRNA or inhibition with chaetocin induced reexpression of silenced AML tumour suppressor genes, consistent with its potential as a therapeutic target.

 

ACCESSION #: NM_003173

Uniprot Link

INCLUDES AMINO ACIDS: 44-412 (C-term.)

TAG(S): N-terminal fusion protein with a C-terminal His-tag

MW: 99.5 kDa

EXPRESSION SYSTEM: E. coli

SUPPLIED AS: Solution of purified recombinant protein in 50 mM Tris/HCl, pH 8.0, 137 mM NaCl, 5 mM MgCl2, 4 mM DTT, 20% (v/v) glycerol

STORAGE: -80°C, aliquot and snap-freeze after first use.

 
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