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SP100-[PHD-BRD] (His)

Your Price:$303.00
In Stock.
Part Number:RD-11-262

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SP100, a component of promyelocytic (PML) nuclear bodies (PML-NBs, aka SP100-PML nuclear bodies, aka nuclear dots), is expressed as four major variants (SP100 A, B, C & HMG) from a single gene. Only one of these, SP100-C, comprises the C-terminal PHD-bromodomain region expressed in this construct. Like the other major component(s) of PML-NBs, the PML proteins, SP100 is considered a tumor suppressor with functions in growth regulation, differentiation, transcription, apoptosis and responses to various stresses, including DNA damage and viral infection. 

ACCESSION #: NM_001080391

Uniprot Link


TAG(S): N-terminal His tag

MW: 23.9 kDa


SUPPLIED AS: Solution of purified recombinant protein in 50 mM Tris HCl, pH 7.5, 500 mM NaCl, 1 mM TCEP, 10% glycerol (v/v)

STORAGE: -70°C. Thaw quickly and store on ice before use. The remaining, unused, undiluted protein should be snap frozen, for example in a dry/ice ethanol bath or liquid nitrogen. Minimize freeze/thaws if possible, but very low volume aliquots (<5 µl) or storage of diluted protein is not recommended.

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With the largest functional kinase activity assay panel in the industry, RBC provides kinase, epigenetic, and other profiling services to over 590 companies worldwide. RBC specializes in custom assay conditions, high quality reproducible data, and outstanding service.

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