SP100, a component of promyelocytic (PML) nuclear bodies (PML-NBs, aka SP100-PML nuclear bodies, aka nuclear dots), is expressed as four major variants (SP100 A, B, C & HMG) from a single gene. Only one of these, SP100-C, comprises the C-terminal PHD-bromodomain region expressed in this construct. Like the other major component(s) of PML-NBs, the PML proteins, SP100 is considered a tumor suppressor with functions in growth regulation, differentiation, transcription, apoptosis and responses to various stresses, including DNA damage and viral infection.
ACCESSION #: NM_001080391
INCLUDES AMINO ACIDS: 700-876
TAG(S): N-terminal GST-tag
MW: 48.1 kDa
EXPRESSION SYSTEM: E. coli
SUPPLIED AS: Solution of purified recombinant protein in 50 mM Tris-HCl pH 7.5, 500 mM NaCl, 1 mM TCEP, 10 % glycerol
STORAGE: -70°C. Thaw quickly and store on ice before use. The remaining, unused, undiluted protein should be snap frozen, for example in a dry/ice ethanol bath or liquid nitrogen. Minimize freeze/thaws if possible, but very low volume aliquots (<5 µl) or storage of diluted protein is not recommended.
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Substantial Discounts Available on Bulk Quantities