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SMYD2 Methyltransferase

Your Price:$358.00
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Part Number:HMT-11-110

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DESCRIPTION:
SMYD2 has been described as a histone H3 (H3K4, H3K36), p53 (p53K370) and Rb (retinoblastoma; RbK860) lysine methyltransferase, although RBC finds this recombinant SMYD2 preparation to be far more active in vitro with recombinant histone H4 than with histone H3, an H3(1-21) peptide, an H4(1-21) peptide, core histones or recombinant p53. SMYD2 is frequently overexpressed in esophageal squamous cell carcinoma (ESCC) and SMYD2 knockdown inhibits the proliferation of SMYD2-overexpressing ESCC cell lines.

ACCESSION #: NM_020197

Uniprot Link

INCLUDES AMINO ACIDS: 2-433 (C-term.)

TAG(S): N-terminal His-tag

MW: 52.0 kDa

EXPRESSION SYSTEM: E. coli

SUPPLIED AS: Solution of purified recombinant protein in 20 mM Tris/HCl, pH 8.0, 120 mM NaCl, 1 mM TCEP, 1 µM ZnCl2, 10% (w/v) glycerol

STORAGE: -80°C, aliquot and snap-freeze after first use.

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With the largest functional kinase activity assay panel in the industry, RBC provides kinase, epigenetic, and other profiling services to over 590 companies worldwide. RBC specializes in custom assay conditions, high quality reproducible data, and outstanding service.

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