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SET7/9 Methyltransferase

Your Price:$329.00
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Part Number:HMT-11-133

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DESCRIPTION:
SET7/9 (SETD7) is a SET domain-containing histone (lysine) methyltransferase, specific for monomethylation.  SET7/9 was originally described as a histone H3 lysine-4 (H3K4) monomethyltransferase.  While it does produce this mark (H3K4me) in vitro with peptide substrates or recombinant histone H3, its activity with nucleosomes is poor.  Recent work has shown SET7/9 to function in the regulation and methylation of multiple non-histone regulatory factors including p53, p65, pRB,TAF10, SIRT1, DNMT1, the androgen receptor (AR), the farnesoid X receptor (FXR) and estrogen receptor a (ER).  SET7/9 action as a coactivator for AR and its promotion of androgen-dependent cell proliferation suggests it as a potential target for prostate cancer therapy.

ACCESSION #: NM_030648

Uniprot Link

INCLUDES AMINO ACIDS: 2-366 (C-term.)

TAG(S): N-terminal GST-tag, C-terminal His-tag

MW: 68.5 kDa

EXPRESSION SYSTEM: E. coli

SUPPLIED AS: Solution of purified recombinant protein in 50 mM Tris/HCl, pH 8.0, 500 mM NaCl, 10% (v/v) glycerol, 2 mM TCEP.

STORAGE: -80°C, aliquot and snap-freeze after first use.

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