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Romidepsin

Part Number:EI-HDC-011
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Romidepsin

FK228; or FR901228; or Depsipeptide


FK228; or FR901228; or Depsipeptide

Romidepsin is a potent and selective inhibitor of class I histone deacetylases (HDACs),IC50 = 36, 47, 510 and 14,000 nM for HDAC1, 2, 4 and HDAC6, respectively1. Induces apoptosis in a variety of cell lines2 and displays antitumor activity in mouse models3. Recently approved for clinical use in T-cell lymphoma4.

Physical Properties: Colorless lyophilized wax. (vials appear empty)

MW=540.7 C24H36N4O6S2

Analysis: >98% (HPLC); NMR (Conforms)

Solubilization: May be dissolved in DMSO (10 mg/ml)

Storage: Store desiccated as supplied at -20°C for up to 2 years. Store solutions at-20°C for up to 1 month.


Amount: 1mg