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Your Price:$253.00
In Stock.
Part Number:EI-HDC-011

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FK228; or FR901228; or Depsipeptide

FK228; or FR901228; or Depsipeptide

Romidepsin is a potent and selective inhibitor of class I histone deacetylases (HDACs),  IC50 = 36, 47, 510 and 14,000 nM for HDAC1, 2, 4 and HDAC6, respectively1. Induces apoptosis in a variety of cell lines2 and displays antitumor activity in mouse models3. Recently approved for clinical use in T-cell lymphoma4.

Physical Properties:  Colorless lyophilized wax. (vials appear empty)

MW=540.7        C24H36N4O6S2

Analysis:  >98% (HPLC); NMR (Conforms)

Solubilization: May be dissolved in DMSO (10 mg/ml)

Storage:  Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month.  

Amount: 1mg

With the largest functional kinase activity assay panel in the industry, RBC provides kinase, epigenetic, and other profiling services to over 590 companies worldwide. RBC specializes in custom assay conditions, high quality reproducible data, and outstanding service.

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