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PRMT8 Methyltransferase

Your Price:$358.00
In Stock.
Part Number:HMT-11-135

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PRMT8, a type I arginine methyltransferase, catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to an w-nitrogen of the guanidino function of protein L-arginine residues (w-monomethylation) and the transfer of a second methyl group to the same nitrogen, yielding asymmetric dimethylarginine (aDMA). Although highly homologous (>80% identity) to the major arginine methyltransferase PRMT1, distinctive characteristics of PRMT8 include a unique, regulatory 76 residue N-terminal domain and its brain-specific expression, especially enhanced in the cortex. Although transfected GFP-PRMT8 can be myristoylated and localized to the plasma membrane, other evidence suggests that the endogenous, central nervous system PRMT8 is a nuclear protein. Removal of the N-terminal 60 amino acids of PRMT8 has been shown to dramatically enhance PRMT8 catalytic activity. RBC’s PRMT8 is deleted for residues 1-60 and is highly active with the substrate GST-GAR.

ACCESSION #: NM_019854

Uniprot Link


TAG(S): N- & C-terminal His-tags

MW: 43.2 kDa


SUPPLIED AS: Solution of purified recombinant protein in 50 mM Tris/HCl, pH 7.5, 125 mM NaCl, 1 mM TCEP, 10% (v/v) glycerol

STORAGE: -80°C, aliquot and snap-freeze after first use.

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We also offer assay services for PRMT8.

With the largest functional kinase activity assay panel in the industry, RBC provides kinase, epigenetic, and other profiling services to over 590 companies worldwide. RBC specializes in custom assay conditions, high quality reproducible data, and outstanding service.

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