PRMT6, a type I arginine methyltransferase, catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to an w-nitrogen of the guanidino function of protein L-arginine residues and the transfer of a second methyl group to the same nitrogen, yielding asymmetric dimethylarginine (aDMA). PRMT6 methylates Arg-2 of histone H3 (H3R2), promoting transcriptional repression.
ACCESSION #: NM_018137
INCLUDES AMINO ACIDS: 2-375 (C-term.)
TAG(S): N-terminal GST-tag
MW: 67.8 kDa
EXPRESSION SYSTEM: E. coli
SUPPLIED AS: Solution of purified recombinant protein in 25 mM Na2HPO4, 4.4 mM KH2PO4, pH 7.4, 137 mM NaCl, 2.7 mM KCl, 3 mM DTT, 30% (w/v) glycerol.
STORAGE: -80°C, aliquot and snap-freeze after first use.
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