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PRMT4 Methyltransferase

Your Price:$439.00
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Part Number:HMT-11-120

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DESCRIPTION:
PRMT4 (CARM1), a type I arginine methyltransferase, catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to an w-nitrogen of the guanidino function of protein L-arginine residues and the transfer of a second methyl group to the same nitrogen, yielding asymmetric dimethylarginine (aDMA).  PRMT4 methylates Arg-17 of histone H3, promoting active transcription.  Other PRMT4 substrates include p300, multiple RNA-binding proteins and splicing factors. PRMT4 acts as a coactivator for various transcription factors, either by binding them directly or, in the case of nuclear receptors, via its interaction with p160 coactivators such as GRP1

ACCESSION #: NM_199141

Uniprot Link

INCLUDES AMINO ACIDS: 2-608 (C-term.)

TAG(S): N-terminal GST-tag

MW: 91.7 kDa

EXPRESSION SYSTEM: E. coli

SUPPLIED AS: Solution of purified recombinant protein in 50 mM HEPES/NaOH, pH 7.1, 180 mM NaCl, 2 mM DTT, 10% (v/v) glycerol.

STORAGE: -80°C, aliquot and snap-freeze after first use.

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