PRMT3, a type I arginine methyltransferase, catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to an omega-nitrogen of the guanidino function of protein L-arginine residues and the transfer of a second methyl group to the same nitrogen, yielding asymmetric dimethylarginine (aDMA). The tumor suppressor DAL-1/4.1B binds PRMT3 and inhibits its activity. DAL-1/4.1B’s capacity to induce apoptosis in the MCF-7 breast cancer cell line is enhanced by elevating cellular levels of the methyltransferase product/inhibitor S-adenosylhomocysteine, suggesting PRMT3 as a potential target for anti-cancer therapeutics.
ACCESSION #: NM_005788
INCLUDES AMINO ACIDS: 2-531 (C-term.)
TAG(S): N-terminal His-tag
MW: 62.0 kDa
EXPRESSION SYSTEM: E. coli
SUPPLIED AS: Solution of purified recombinant protein in 50 mM HEPES/KOH, pH 7.6, 100 mM KCl, 3 mM DTT, 30% (w/v) glycerol. .
STORAGE: -80°C, aliquot and snap-freeze after first use.
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