NSD3 (WHSC1L1) is a SET-domain lysine methyltransferase thought to primarily methylate H3K36, a mark associated with gene activation, although activities at H3K4 and H3K27 have also been reported. NSD3 forms a complex with bromodomain protein 4 (Brd4) where it functions in transcriptional activation. Both proteins are required for H3K36 trimethylation (H3K36me3) in the gene bodies of Brd4 targets. NSD3 is overexpressed in significant subsets of human lung and breast cancers and is considered a promising target for the development of anti-cancer therapies.
ACCESSION #: NM_023034
INCLUDES AMINO ACIDS: 1021-1322
TAG(S): N-terminal GST-tag
MW: 66.7 kDa
EXPRESSION SYSTEM: E. coli
SUPPLIED AS: Solution of purified recombinant protein in 50 mM Tris/HCl pH 8.0, 125 mM NaCl, 3 mM DTT, 10% glycerol (v/v).
STORAGE: -80°C, aliquot and snap-freeze after first use.
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