MS-275 is a potent and selective non-hydroxamate HDAC inhibitor. Considered to be a class I
selective inhibitor but displays some selectivity amongst class I members: HDAC1 (IC50 = 0.3 mM); HDAC3 (IC50 = 8 mM) with no inhibition of HDAC8 (at
>100 mM)1. Induces
hyperacetylation of nuclear histones in tumor cells resulting in inhibition of
proliferation of a variety of human tumor cell lines2. Protects p53-deficient mice against ischemic injury3.
Supresses the p38 MAP kinase pathway in rheumatoid arthritic synovial
fibroblasts4. Active in vivo.
Physical Properties: Pale yellow
Analysis: >98% (TLC); NMR
Solubilization: May be dissolved in DMSO (25 mg/ml, warm)
Storage: Store desiccated as
supplied at -20°C for up to 1 year. Store solutions at -20°C for up to 1 week.