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MS-275

Your Price:$60.50
In Stock.
Part Number:EI-HDC-007

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MS-275  



Pyridin-3-ylmethyl 4-((2-aminophenyl)carbamoyl)benzylcarbamate; Entinostat

MS-275 is a potent and selective non-hydroxamate HDAC  inhibitor. Considered to be a class I selective inhibitor but displays some selectivity amongst class I members:  HDAC1 (IC50 = 0.3 mM); HDAC3 (IC50 = 8 mM) with no inhibition of HDAC8 (at >100 mM)1. Induces hyperacetylation of nuclear histones in tumor cells resulting in inhibition of proliferation of a variety of human tumor cell lines2.  Protects p53-deficient mice against ischemic injury3. Supresses the p38 MAP kinase pathway in rheumatoid arthritic synovial fibroblasts4. Active in vivo.

Physical Properties:  Pale yellow powder

MW=376.4          C21H20N4O3

Analysis:  >98% (TLC); NMR (Conforms)

Solubilization: May be dissolved in DMSO (25 mg/ml, warm)

Storage:  Store desiccated as supplied at -20°C for up to 1 year. Store solutions at -20°C for up to 1 week.



Amount: 5mg










With the largest functional kinase activity assay panel in the industry, RBC provides kinase, epigenetic, and other profiling services to over 590 companies worldwide. RBC specializes in custom assay conditions, high quality reproducible data, and outstanding service.

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