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MLL2 Complex

Your Price:$549.00
In Stock.
Part Number:HMT-15-106

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MLL2 Complex is a complex catalyzing the transcription-activating methylation of histone H3 lysine-4 and comprising a catalytic, SET domain-containing subunit, MLL2, plus the subunits of an activity-enhancing sub-complex—WDR5, RbBP5, Ash2L and DPY-30 (2 copies). MLL2 expression is elevated in breast and colon cancer cell lines and in both breast and colon tumor tissue, suggesting that MLL2 Complex may represent a therapeutic target for these cancers and possibly solid tumors in general.

ACCESSION #: NM_003482, NM_017588, NM_005057, NM_001105214, NM_0325742

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INCLUDES AMINO ACIDS: MLL2 5319-5537 (C-term.), WDR5 22-334 (C-term.), RbBP5 1-538 (C-term.), Ash2L 2-534 (C-term.), DPY-30 1-99 (C-term.)

TAG(S): N-terminal His-tag on all subunits

MW: 211.0 kDa


SUPPLIED AS: Solution of purified recombinant proteins in 20 mM Tris-HCl, pH 7.5, 300 mM NaCl, 1 mM TCEP (tris(2-carboxyethyl)phosphine HCl), 10% (w/v) glycerol, 1 µM ZnCl2.

STORAGE: -80°C, aliquot and snap-freeze after first use.

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With the largest functional kinase activity assay panel in the industry, RBC provides kinase, epigenetic, and other profiling services to over 590 companies worldwide. RBC specializes in custom assay conditions, high quality reproducible data, and outstanding service.

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