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Your Price:$71.50
In Stock.
Part Number:EI-DEM-009

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JIB-04 is a novel specific inhibitor of the Jumonji family of histone demethylases in vitro, in cancer cells and in tumors in vivo. IC50 = 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively.  Reduces tumor burden and prolongs life in a mouse model. Suppresses translation initiation and enhances mTOR inhibitor sensitivity. Inhibits the growth of temozolomide-resistant glioblastoma cells and crosses the blood brain barrier.

Physical Properties: Yellow powder

MW=308.8          C17H13ClN4

Analysis:  >98% (TLC); NMR (Conforms)

Solubilization: May be dissolved in DMSO (30 mg/ml)

Storage:  Store desiccated as supplied at -20°C temperature for up to 2 years. Store solutions at -20°C for up to two months.

Amount: 5 mg 

With the largest functional kinase activity assay panel in the industry, RBC provides kinase, epigenetic, and other profiling services to over 590 companies worldwide. RBC specializes in custom assay conditions, high quality reproducible data, and outstanding service.

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