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JIB-04

Your Price:$71.50
In Stock.
Part Number:EI-DEM-009

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JIB-04   


(E)-5-chloro-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)pyridine


https://reactionbiology-com.3dcartstores.com/admin/iteminfo.asp?catid=296&pannel=1


JIB-04 is a novel specific inhibitor of the Jumonji family of histone demethylases in vitro, in cancer cells and in tumors in vivo. IC50 = 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively.  Reduces tumor burden and prolongs life in a mouse model. Suppresses translation initiation and enhances mTOR inhibitor sensitivity. Inhibits the growth of temozolomide-resistant glioblastoma cells and crosses the blood brain barrier.

Physical Properties: Yellow powder

MW=308.8          C17H13ClN4

Analysis:  >98% (TLC); NMR (Conforms)

Solubilization: May be dissolved in DMSO (30 mg/ml)

Storage:  Store desiccated as supplied at -20°C temperature for up to 2 years. Store solutions at -20°C for up to two months.


Amount: 5 mg 











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