JIB-04 is a novel specific inhibitor of the Jumonji family of histone
demethylases in vitro, in cancer
cells and in tumors in vivo. IC50 = 230,
340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and
JMJD2C respectively. Reduces tumor burden and prolongs life in a
mouse model. Suppresses translation initiation and enhances mTOR inhibitor
sensitivity. Inhibits the growth of temozolomide-resistant glioblastoma cells
and crosses the blood brain barrier.
Physical Properties: Yellow powder
Analysis: >98% (TLC); NMR
Solubilization: May be dissolved in
DMSO (30 mg/ml)
Storage: Store desiccated as
supplied at -20°C temperature for up to
2 years. Store solutions at -20°C for up to two months.
Amount: 5 mg