IDH (isocitrate dehydrogenase) proteins are involved in hypermethylating DNA and histones, which can result in altered gene expression that can activate oncogenes and inactivate tumor-suppressor genes. IDH proteins play a role in several types of brain tumors, acute myeloid leukemia, and rare tumoral diseases like Ollier disease suggesting that IDH proteins are involved in tumorigenesis in a wide range of tumor lineages. Reaction Biology offers IDH proteins for purchase and for assay services.