customer service

Histone H2B

Your Price:$55.00
In Stock.
Part Number:HMT-11-147

Choose Options


**Please note that shipping and dry ice charges will be included in your final invoice.**

Full-length, untagged human recombinant histone H2B expressed in E. coli. One of the four, core nucleosomal histones, H2B forms dimers with histone H2A, two of which associate with the H3-H4 tetramer (H3-H4)2, forming the core octamer of the nucleosome. Histone H2B is subject to several regulatory post-translational modifications including monoubiquitination, phosphorylation, acetylation, lysine methylation and crotonylation. Monoubiquitination of H2B lysine-120 (H2BK120ub) stimulates H3K4 methylation in chromatin, an effect which recent evidence suggests is mediated in trans via ubiquitin binding by Ash2L, a component of the human MLL/SET1 family methyltransferase complexes. Monoubiquitination at both H2BK34 and H2BK120 has been shown to enhance H3K79 methylation by Dot1L. RBC’s Histone useful for the assay of histone acetyltransferases (HATs; e.g. p300, CBP) either by radiolabeling with [3H]-S-adenosylmethionine (e.g. gel electrophoresis/autoradiography or filterplate/scintillation counting) or by non-radiolabeled methods (e.g. detection with site-specific anti-acetyllysine antibodies). 

ACCESSION #: NM_0080593

Uniprot Link


TAG(S): None

MW: 13.9 kDa


SUPPLIED AS: Solution of purified recombinant protein in 50 mM HEPES/NaOH pH 7.1, 10 mM KCl, 1 mM DTT, 1 mM EDTA, 10% glycerol (v/v).

STORAGE: -80°C, aliquot and snap-freeze after first use.

View Product Data Sheet

 Substantial Discounts Available on Bulk Quantities

With the largest functional kinase activity assay panel in the industry, RBC provides kinase, epigenetic, and other profiling services to over 590 companies worldwide. RBC specializes in custom assay conditions, high quality reproducible data, and outstanding service.

Reaction Biology Corp. 1 Great Valley Parkway, Suite 2 Malvern, PA 19355 1-877-347-2368 or 610-722-0247
[email protected]
Reaction Biology Corp. © 2013 all rights reserved.