Hexyl-4-pentynoic acid is a valproic acid analog. Histone deacetylase
(HDAC) inhibitor, IC50=13 mM1.
More potent and robust than valproic acid at inducing histone hyperacetylation
(600% at 50 mM), HSP70 induction and protection against
glutamate excitotoxicity in cultured neurons. Cell permeable.
Physical Properties: colorless oil
Analysis: >97% (TLC); NMR conforms
Solubilization: May be dissolved in DMSO (25
mg/ml); or Ethanol (25 mg/ml)
Store as supplied at ambient temperature for up to 2 years. Store
solutions at -20°C for up to 3 months.