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GSK-J4 (cell permeable)

Your Price:$84.70
In Stock.
Part Number:EI-DEM-002

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N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-ß-alanine ethyl ester

GSK-J4 is a histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 µM for the inhibition of TNFa release). Cell permeable, ethyl ester of GSK-J1. Rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies. Inhibits the growth of T-cell acute lymphoblastic leukemia (T-ALL) cells.

Physical Properties:  Yellow wax

MW=417.5        C24H27N5O2

Analysis:  >99% (TLC); NMR (Conforms)

Solubilization: May be dissolved in DMSO (40 mg/ml); or ethanol (40 mg/ml)

Storage:  Store, as supplied, at -20°C. Store solutions at -20°C for up to 3 months.

Amount: 5mg

With the largest functional kinase activity assay panel in the industry, RBC provides kinase, epigenetic, and other profiling services to over 590 companies worldwide. RBC specializes in custom assay conditions, high quality reproducible data, and outstanding service.

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