customer service

GSK-J1 (cell impermeable)

Your Price:$88.00
In Stock.
Part Number:EI-DEM-001

**Please note that shipping and dry ice charges will be included in your final invoice.**


GSK-J1 is a potent and selective inhibitor of jumonji H3K27 histone demethylases JMJD3 and UTX (IC50 = 60 nM, human JMJD3). This is the first known inhibitor selective for the H3K27me3-specific JMJ subfamily which binds to the active catalytic site of the enzyme. The COOH group confers cell impermeability and as such is useful as a standard in in vitro assays. A cell permeable ethyl ester analog (GSK-J4) is also available.

Physical Properties:  Pale yellow powder

MW=389.5        C22H23N5O2

Analysis:  99% (TLC); NMR (Conforms)

Solubilization: May be dissolved in DMSO (20 mg/ml, warm)

Storage:  Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20°C for up to 3 months.  

Amount: 5mg

With the largest functional kinase activity assay panel in the industry, RBC provides kinase, epigenetic, and other profiling services to over 590 companies worldwide. RBC specializes in custom assay conditions, high quality reproducible data, and outstanding service.

Reaction Biology Corp. 1 Great Valley Parkway, Suite 2 Malvern, PA 19355 1-877-347-2368 or 610-722-0247
[email protected]
Reaction Biology Corp. © 2013 all rights reserved.