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G9a/GLP Complex Methyltransferase

Your Price:$358.00
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Part Number:HMT-12-104

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In vivo, a heterodimeric complex of the related SET-domain histone methyltransferases (HMTs) G9a and GLP is the major source of mono- and dimethylated histone H3K9 in euchromatin, marks associated with recruitment of HP1, DNA methylation and gene silencing. Per mole of G9, GLP or (G9a + GLP), this equimolar mixture displays activity well in excess of G9a alone, similar to the more active GLP, suggesting a significant degree of heterodimer formation.

ACCESSION #: NM_006709, NM_024757

Uniprot Link
Uniprot Link 2

INCLUDES AMINO ACIDS: G9a 786-1210 (C-term.), GLP 894-1298 (C-term.)

TAG(S): N-terminal GST-tag on both

MW: 80.0/80.00 kDa


SUPPLIED AS: Solution of purified recombinant proteins in 25.4 mM Na2HPO4/NaH2PO4, pH 7.4, 137 mM NaCl, 2.7 mM KCl, 3 mM DTT, 30% (w/v) glycerol.

STORAGE: -80°C, aliquot and snap-freeze after first use.

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With the largest functional kinase activity assay panel in the industry, RBC provides kinase, epigenetic, and other profiling services to over 590 companies worldwide. RBC specializes in custom assay conditions, high quality reproducible data, and outstanding service.

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