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EX-527

Part Number:EI-SRT-006
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EX-527


6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide (racemic)

EX-427 is a selective Sirt1 inhibitor (IC50=98 nM). Does not inhibit other HDACs or Sirt family members. Increases p53 acetylation following DNA damage. Causes cell cycle arrest at G1. Inhibits differentiation and facilitates expansion of hematopoietic progenitor cells. An extremely useful tool for determining the involvement of Sirt1 in cellular physiology. Cell permeable.

Physical Properties: Light yellow powder

MW=248.7 C13H13ClN2O

Analysis: >98% (TLC); NMR (Conforms)

Solubilization: May be dissolved in DMSO (18 mg/ml); or Ethanol (10 mg/ml)

Storage: Store desiccated as supplied at 4°C for up to 2 years. Store solutions at-20°C for up to 2 months.