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EP300 (His)

Part Number:RD-11-222
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Human recombinant EP300 bromodomain. EP300 and the closely related CREBBP (CBP) are major regulators of gene transcription (co-activators) and function as lysine acetyltransferases for histones (i.e. HATs) and for numerous other proteins (e.g. p53). Aside from the acetyllysine-binding bromodomain and the catalytic HAT domain, native EP300 comprises multiple protein-protein interaction domains (3 Cys-His-rich (CH) domains, KIX domain, steroid receptor co-activator interaction domain (SID)) and also has E3 and E4 ubiquitin ligase activities.

ACCESSION #: NM_001429

Uniprot Link

INCLUDES AMINO ACIDS: 1040-1161

TAG(S): N-terminal His-tag

MW: 17.2 kDa

EXPRESSION SYSTEM: E. coli

SUPPLIED AS: Solution of purified recombinant protein in 50 mM Tris HCl, pH 7.5, 500 mM NaCl, 1 mM TCEP, 10% glycerol (v/v)

STORAGE: -70°C. Thaw quickly and store on ice before use. The remaining, unused, undiluted protein should be snap frozen, for example in a dry/ice ethanol bath or liquid nitrogen. Minimize freeze/thaws if possible, but very low volume aliquots (<5 µl) or storage of diluted protein is not recommended.

 
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