RBC currently offers LSD1 and CoRest as a part of their protein demethylation collection. LSD1 and CoRest are histone demethylases that, depending on the context, act as coactivators or as corepressors. Working alone and together, LSD1 and CoRest demethylate H3K4me and H3K9me of histone H3 which are specific tags for epigenetic transcriptional activation and repression in turn. LSD1 is a promising target for drug development, as its expression is elevated in a number of cancers. LSD1 and CoRest are useful for studying inhibitor sensitivity and the effect of the enzymes in transcriptional regulation, cell cycle progression, and oncogenesis. Reaction Biology offers CoRest for purchase and LSD1 for purchase and for assay services.