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Decitabine

Part Number:EI-DNA-001
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Decitabine

5-Aza-2’-deoxycytidine; 5-AzadCyD; NSC-127716

Decitabine inhibits DNA methyltransferase. Induces demethylation and reactivation of silenced genes suppressing the growth of human tumor cell lines. Increases stem cell reprogramming efficiency. Stimulates osteogenic differentiation of human bone marrow stromal cells. Induces differentiation and growth inhibition in IDH1 mutant glioma cells and decreases tumor growth in vivo. An extremely useful reagent for inhibition of DNA methyltransferases in a variety of experimental systems including zebrafish embryos. Cell permeable. Active in vivo.

Physical Properties: White powder; MP=193-196°C

MW=228.2 C8H12N4O4

Analysis: >98% (TLC); NMR (Conforms)

Solubilization: May be dissolved in DMSO (25 mg/ml); or water (11 mg/ml).Ethanol (nil)

Storage: Store desiccated as supplied at 4°C for up to 2 years. Store solutions at-20°C for up to 3 months.

Amount: 10mg