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Daminozide

Your Price:$49.50
In Stock.
Part Number:EI-DEM-006

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Daminozide




1-(2,2-Dimethylhydrazide)butanedioic acid; N-(dimethylamino)succinamic acid,



Daminozide is a selective inhibitor of the KDM2/7 JmjC subfamily of histone demethylases. IC50=1.5, 0.55 and 2.1 mM for KDM2A, PHF8 and KDM7A respectively. Highly selective over other subfamily members (KDM3, KDM4, KDM5 and KDM6) as well as other 2-oxoglutarate oxygenases (FIH, PHD2 and BBOX1), IC50>100 mM

Physical Properties:  White powder; MP=158-162°C

MW=160.2          C6H12N2O3

Analysis:  98% (TLC); NMR (Conforms)

Solubilization: May be dissolved in DMSO (50 mg/ml); or water (20 mg/ml, warm)

Storage:  Store desiccated as supplied at ambient temperature for up to 3 years. Store solutions at -20°C for up to 3 months.

 
Amount: 50mg










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