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Your Price:$52.00
In Stock.
Part Number:EI-DEM-006

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1-(2,2-Dimethylhydrazide)butanedioic acid; N-(dimethylamino)succinamic acid,

Daminozide is a selective inhibitor of the KDM2/7 JmjC subfamily of histone demethylases. IC50=1.5, 0.55 and 2.1 mM for KDM2A, PHF8 and KDM7A respectively. Highly selective over other subfamily members (KDM3, KDM4, KDM5 and KDM6) as well as other 2-oxoglutarate oxygenases (FIH, PHD2 and BBOX1), IC50>100 mM

Physical Properties:  White powder; MP=158-162°C

MW=160.2          C6H12N2O3

Analysis:  98% (TLC); NMR (Conforms)

Solubilization: May be dissolved in DMSO (50 mg/ml); or water (20 mg/ml, warm)

Storage:  Store desiccated as supplied at ambient temperature for up to 3 years. Store solutions at -20°C for up to 3 months.

Amount: 50mg

With the largest functional kinase activity assay panel in the industry, RBC provides kinase, epigenetic, and other profiling services to over 590 companies worldwide. RBC specializes in custom assay conditions, high quality reproducible data, and outstanding service.

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