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DZNep

Part Number:EI-HMT-004
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DZNep

3-Deazaneplanocin A; (1S,2R,5R)-5-(4-aminoimidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-cyclopent-3-ene-1,2-diol; NSC 617989

Potent histone methyltransferase inhibitor which decreases global histone methylation. Inhibits trimethylation of H3K27 and H4K20 in vitro. Selectively induces apoptosis in multiple cancer cell lines with no effect on normal cells. May be used in cocktails to chemically induce pluripotent stem cells (CiPSCs) from somatic cells. Enhances angiogenesis in a mouse model of limb ischemia.

Physical Properties: Beige powder

MW= 262.3 C12H14N4O3

Analysis: =98% (HPLC); NMR (Conforms)

Solubilization: May be dissolved in DMSO (20 mg/ml)

Storage: Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month.


Amount: 1mg