Potent histone methyltransferase inhibitor which decreases global
histone methylation. Inhibits trimethylation of H3K27 and H4K20 in vitro. Selectively induces
apoptosis in multiple cancer cell lines with no effect on normal cells. May be
used in cocktails to chemically induce pluripotent stem cells (CiPSCs) from
somatic cells. Enhances angiogenesis in a mouse model of limb ischemia.
Physical Properties: Beige powder
Analysis: =98% (HPLC); NMR (Conforms)
Solubilization: May be dissolved in DMSO
Storage: Store desiccated as supplied at -20°C for up to 2 years. Store solutions
at -20°C for up to 1 month.