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DOT1L Methyltransferase

Your Price:$435.00
In Stock.
Part Number:HMT-11-101

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Human DOT1L, and its homologs in other species, are unique among the histone lysine methyltransferases in not containing a SET domain and in targeting a specific residue in the histone H3 globular domain (lysine-79; H3K79).  Inappropriate recruitment of DOT1L by MLL-fusion proteins is implicated in the development of leukemias. 

ACCESSION #: NM_032482

Uniprot Link


TAG(S): N-terminal GST

MW: 80.0 kDa


SUPPLIED AS: Solution of purified recombinant protein in 25 mM Tris-HCl, pH 7.5, 100 mM NaCl, 0.05% Tween 20, 3 mM DTT, 20% (v/v) glycerol.

STORAGE: -80°C, aliquot and snap-freeze after first use.

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Substantial Discounts Available on Bulk Quantities

We also offer assay services for DOT1L.

With the largest functional kinase activity assay panel in the industry, RBC provides kinase, epigenetic, and other profiling services to over 590 companies worldwide. RBC specializes in custom assay conditions, high quality reproducible data, and outstanding service.

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