DNMT3b, a de novo DNA methyltransferase, is essential in development and can mediate gene silencing.Overexpression and/or gene amplification of DNMT3b, along with DNA hypermethylation, have been observed in a number of cancers, suggesting that DNMT3b is an oncogene and a promising therapeutic target.For example, DNMT3b expression and DNA methylation are elevated in a subset of breast cancers and both specific knockdown of DNMT3b expression and chemical inhibition of DNMTs enhance the sensitivity of breast cancer lines with this hypermethylation phenotype to cytotoxic chemotherapy agents.

SUPPLIED AS: Solution of purified recombinant protein in 50 mM Tris/HCl pH 8.0, 150 mM NaCl, 3 mM DTT, 10% glycerol (v/v).

STORAGE: -80°C, aliquot and snap-freeze after first use.