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DMOG

Part Number:EI-DEM-004
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DMOG


N-(2-Methoxy-2-oxoacetyl)glycine methyl ester; Dimethyloxalylglycine


DMOG inhibits PHD or prolyl hydroxylase domain-containing proteins, activating HIF1a and inhibiting JMJD2A (IC50 = 2.5 mM). Displays neuroprotective effects. Inhibits neuronal cell death caused by neurotrophin deprivation. Prevents activation of the ATR/CHK1/p53 pathway and suppresses apoptosis induced by DNA damage.


Physical Properties: White to off-white solid; MP=46-48°C

MW=175.1 C6H9NO5

Analysis: >98% (TLC); NMR (Conforms)

Solubilization: May be dissolved in DMSO (30 mg/ml), ethanol (25 mg/ml), or water (30 mg/ml)

Storage: Store desiccated as supplied at -20°C for up to 2 years. Store solutions at-20°C for up to 1 month.

Amount:10 mg