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Your Price:$143.00
In Stock.
Part Number:EI-HDC-010

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CUDC-101 is a novel hybrid dual-acting HDAC and receptor tyrosine kinase inhibitor. It is a potent HDAC inhibitor which also inhibits EGFR and HER2,  IC50 = 4.4, 2.4 and 15.7 nM respectively. It not only blocks EGFR and HER2 but also attenuates multiple compensatory pathways such as AKT, HER3 and MET which enable tumor cells to escape the effects of conventional EGFR/HER2 inhibitors

Physical Properties:  White to off-white powder

MW = 434.5        C24H26N4O4

Analysis:  >99% (HPLC); NMR (Conforms); MP=188-190oC

Solubilization: May be dissolved in DMSO (25 mg/ml)

Storage:  Store desiccated as supplied at -20°C for up to 2 years. Store solutions at            -20°C for up to 1 month.  

Amount: 5mg


With the largest functional kinase activity assay panel in the industry, RBC provides kinase, epigenetic, and other profiling services to over 590 companies worldwide. RBC specializes in custom assay conditions, high quality reproducible data, and outstanding service.

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