Human recombinant CREBBP bromodomain. CREBBP and the closely related p300 are major regulators of gene transcription (co-activators) and function as lysine acetyltransferases for histones (i.e. HATs) and for numerous other proteins (e.g. p53). Aside from the acetyllysine-binding bromodomain and the catalytic HAT domain, native CREBBP comprises multiple protein-protein interaction domains (3 Cys-His-rich (CH) domains, KIX domain, steroid receptor co-activator interaction domain (SID)) and also has E3 and E4 ubiquitin ligase activities.
ACCESSION #: NM_004380
INCLUDES AMINO ACIDS: 1081-1197
TAG(S): N-terminal His tag
MW: 16.7 kDa
EXPRESSION SYSTEM: E.coli
SUPPLIED AS: Solution of purified recombinant protein in 50 mM Tris/HCl, pH 7.5, 500 mM NaCl, 1.0 mM TCEP, 10% glycerol (v/v)
STORAGE: -70°C. Thaw quickly and store on ice before use. The remaining, unused, undiluted protein should be snap frozen, for example in a dry/ice ethanol bath or liquid nitrogen. Minimize freeze/thaws if possible, but very low volume aliquots (<5 µl) or storage of diluted protein is not recommended.
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Substantial Discounts Available on Bulk Quantities
We also offer assay services for CREBBP (His).