CI-994 is an orally active histone deacetylase (HDAC) inhibitor, IC50 = 0.9,
0.9, 1.2 and >20 µM for HDAC1, HDAC2, HDAC3 and HDAC8 respectively.
Mediates G1 cell cycle arrest, inhibits proliferation and induces
apoptosis in vitro and in vivo. Increase
neuroplasticity during memory extinction. Protects beta cells from
Physical Properties: Off-white powder
Analysis: >98% (TLC); NMR
Solubilization: May be dissolved in DMSO (25 mg/ml)
Storage: Store desiccated as
supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month.