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CI-994

Part Number:EI-HDC-012
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CI-994

N-acetyldinaline; 4-(Acetylamino)-N-(2-aminophenyl)benzamide; PD-123654

CI-994 is an orally active histone deacetylase (HDAC) inhibitor, IC50 = 0.9, 0.9, 1.2 and >20 µM for HDAC1, HDAC2, HDAC3 and HDAC8 respectively. Mediates G1 cell cycle arrest, inhibits proliferation and induces apoptosis in vitro and in vivo. Increase neuroplasticity during memory extinction. Protects beta cells from cytokine-induced apoptosis.

Physical Properties: Off-white powder

MW=269.3 C15H15N3O2

Analysis: >98% (TLC); NMR (Conforms)

Solubilization: May be dissolved in DMSO (25 mg/ml)

Storage: Store desiccated as supplied at -20°C for up to 2 years. Store solutions at-20°C for up to 1 month.


Amount: 5mg