Human recombinant CECR2 bromodomain. CECR2, along with SMARCA1 (SNF2L) forms the ATP-dependent chromatin remodeling complex CERF and plays an essential role in neural tube formation. The CECR2 bromodomain displays binding affinity for mutiple histone H2A and H3 Lys(Ac) residues in singly acetylated histone peptide microarrays (H2A: K15Ac, K36Ac, K75Ac; H3: K9Ac, K14Ac, K18Ac & others), with the H3K9Ac and H3K14Ac interactions confirmed by isothermal titration calorimetry (ITC). A crystal structure for the CECR2 binding domain has been determined.
ACCESSION #: NM_031413
INCLUDES AMINO ACIDS: 425-538
TAG(S): N-terminal His tag
MW: 16.4 kDa
EXPRESSION SYSTEM: E.coli
SUPPLIED AS: Solution of purified recombinant protein in 50 mM Tris/HCl, pH 7.5, 500 mM NaCl, 1.0 mM TCEP, 10% glycerol (v/v)
STORAGE: -70°C. Thaw quickly and store on ice before use. The remaining, unused, undiluted protein should be snap frozen, for example in a dry/ice ethanol bath or liquid nitrogen. Minimize freeze/thaws if possible, but very low volume aliquots (<5 µl) or storage of diluted protein is not recommended.
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Substantial Discounts Available on Bulk Quantities
We also offer assay services for CECR2 (His).